Bacteriophage
multivalent

Composition:

1 vial (20 ml) contains a sterile solution of bacteriophage (sterile mixture of purified bacterial phagolysis filtrates), which causes specific lysis of bacteria of the genus Staphylococcus: Staphylococcus aureus, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus hyicus, (можливо також Staphylococcus cohnii, Staphylococcus сарitis, Staphylococcus intermedius); Streptococcus: Str.pyogenes, Str.pneumoniae, Str.agalactiae, Str.viridans; роду E.coli; роду Enterococcus: Ent.faecalis, Ent.faecium, Ent.durans; роду Klebsiella: Kl.pneumoniae Kl.oxytoca, Kl.terrigena, Klebsiella ozaenae; роду Proteus: Pr.vulgaris, Pr.mirabilis, Pr.peneri; роду Pseudomonas: Ps.aeruginosa, Ps.maltophilia, Ps.alcaligenes, Ps.stutzeri, Ps.fluorescens with the concentration of phage particles at least 10⁵ microorganisms/ml.

Release form:

Liquid.

Package:

A vial 20ml 5 bottles in a box or a separate vial 100ml.

Shelf life:

2 years in a closed vial.

Physico-chemical properties:

Transparent, colorless or light yellow, liquid of varying color intensity with a neutral or weak specific odor.

Pharmacological properties:

The preparation in local contact action has the ability to specifically ling (destroy, neutralize) bacteria of the genus staphylococci, streptococci, Escherichia coli, enterococci, klebsiel, protei and a Pseudomonas aeruginosa regardless of their sensitivity or antibiotic resistance.

Indications

Multivalent bacteriophagus is shown for ingestion and topical use in acute, prolonged, delayed, chronic and recurrent diseases caused by staphylococci, streptococci, Escherichia coli, enterococci, klebsiels, proteins and a nonantibiotic therapy, or with the resistance of strains of the pathogen to antibiotics (including - against hospital strains), as well as in combination treatment, including - simultaneously with the use of antibiotics, or for prevention:

— with intestinal dysbiosis and disorders of intestinal flora biocenosis;
— in purulent-inflammatory processes associated with bacteria of the genus Staphylococcus, Streptococcus, E.coli, Enterococcus, Klebsiella, Proteus, Pseudomonas;
— in the nasopharynx (rhinitis, including bacterial-associated allergic rhinitis, pollinosis, vasomotor rhinitis, inflammation of the sinuses of the nose, sore throats, pharyngitis);
— in the mouth (stomatitis, glorify);
— in ears (middle ear inflammation, hearing aisle dermatitis);
— gums and teeth (gingivitis, periodontitis);
— in the eyes (purulent conjunctivitis, keratoconjuxt, purulent ulcers of the cornea and iridocyclitis);
— respiratory tract and lungs (laryngitis, tracheitis, bronchitis, pneumonia, pleurisy, infectious-allergic form of bronchial asthma), including for bronchial washing during bronchoscopy;
— in the urogenital system (urethritis, cystitis, pyelonephritis, colitis, endometritis, salpingoophoritis, balanopostitis, prostatitis);
— pyelonephritis of transplanted kidneys, especially in cases caused by hospital strains of phagoagid bacteria;
— in purulent-inflammatory diseases of bones, joints and ligaments (osteomyelitis, bursitis, purulent arthritis, including postoperative and after joint transplantation);
— in bacterial toxicoderma (erysipelas, atopic and other variants of dermatitis, eczema, psoriasis, etc.);
— in surgical infections (suppuration of wounds, postoperative complications, burns, abscesses, phlegmon, gangrene, trophic ulcers mainly lower extremities, recurrent cysts of coccyx, paraproctitis, etc.);
— in purulent-inflammatory diseases of newborns (omphalitis, dacryocystitis, pyoderma, including generalized pyoderma of the head, conjuxtic, gastroenterocolitis, sepsis, etc.);
— other diseases caused by or as a medicine infection with phagosensitive strains above the listed bacteria.

Features of application

● Before using the preparation, it is advisable to determine by bacteriological examination the sensitivity of the pathogen to the multivalent primabag.

● Before use the preparation must be shaken!

● Not to use when turbid!

● Do not use for parenteral injections!

When opening the vial, selection and storage of the preparation, you must follow the following rules:

— wash your hands thoroughly;
— protective cap before removal should be treated with alcohol -containing solution;
— the protective cap to remove without removing the rubber plug;
— the preparation from an open vial to select a sterile syringe (by puncture of rubber tube), when using small doses of the preparation it is necessary to use a new sterile syringe with a needle for each selection of the preparation;
— if the plug was removed when opening the vial, it is not necessary to put it on the table with an inner surface;the bottle should not be left open;it should be closed after a preparation selection;
— closed vial should be stored in the refrigerator!

Since the preparation is stored in the refrigerator, then before use the preparation in the syringe after selection from the vial should be brought to room temperature.

In compliance with the above rules, reservations and storage conditions and in the absence of opacification, the preparation from the open vial can be used throughout the shelf life.

The method of application and dose

● Before applying a bacteriophage, a doctor's consultation or advice is recommended.

● In intestinal forms of the disease and dysbiosis of the intestine, associated with phagosensitive strains of bacteria, take inside 3-4 times a day for 30-45 minutes before meals depending on age: adults-15-20 ml, children from 3 years-10-15 ml, children up to 3-2 in 5-10 ml..

Locally used in the form of irrigation, lotions, rinsing, infusion, washing, instillation, tamming, turund, applications, etc.within 10-20 days depending on clinical indications:

— In purulent-inflammatory diseases in the nasopharynx (rhinitis, including bacterial-associated allergic rhinitis, pollinosis, vasomotor rhinitis, inflammation of the sinuses of the nose, sore throat, pharyngitis), the preparation is injected at a dose of 1.0–2.5 ml (depending on the age of сuckoo).
— In the treatment of stomatitis, glossitis, gingivitis and chronic generalized periodontitis, the preparation is used in the form of mouth rinses 3-4 times a day at a dose of 10-20 ml, holding a phage solution in the mouth for 10-15 minutes, and also make applique on the area of gums or ink..
— In conjunctivitis, the preparation is purchased 2–3 drops 4–5 times a day, with keratoconjuxtivitis and purulent ulcer of the cornea - 4–5 drops, with purulent iridocyclitis, the preparation is used 6-8 drops every 3 hours in combination with intrudal intake.
— In purulent-inflammatory diseases of the ear (otitis), dermatitis, itching of the auditory passages used moistened with bacteriophage of turunda for 15-20 minutes in the morning and evening.
— In recurrent cystitis, the preparation is administered by instillation into the bladder.If the bladder or renal pelvic cavity is drained, the bacteriophage is injected through a cystostomy (into the bladder) or nephrostomy 1-2 times a day for 20-50 ml for at least 10-12 days.
— In purulent-inflammatory gynecological diseases, the preparation is injected into the vaginal cavity, the uterus after rehabilitation with a tampon for 20-25 minutes, spreading the tampon with the preparation until fully leaked (to the first drop).
— In abscesses and treatment of open wound surfaces, the bacteriophage is injected into the cavity after removal of pus by means of puncture, or by applique to the wound surface after its preliminary rehabilitation with disinfectant solutions.Doses of the preparation are determined by the nature of the foci of infection and make up from 15-20 ml (for infusions into the wound with osteomyelitis) up to 100-200 ml for administration into the cavity (pleural, peritoneal, foci after removal.

Interaction with other medicines

The use of bacteriophage is possible simultaneously with the use of other antibacterial preparations, including antibiotics.Incompatibility with other medicines not described.

Contraindication:

Missing.

Local reactions:

Hypersensitivity reactions are possible.

Side action:

Not set.

Overdose:

Not noted.

The use of the drug during pregnancy and breastfeeding:

The use of bacteriophages during pregnancy and during breastfeeding is possible in the presence of infections caused by phagosized strains of bacteria (on the recommendation of a doctor).

Information on possible effect on the speed of reaction when driving a motor transport or other mechanisms:

Missing.

Instruction - liner